Extended Data Fig. 7: Pan-Organ fibrosis gene set at single cell resolution.
From: Decoding the hallmarks of allograft dysfunction with a comprehensive pan-organ transcriptomic atlas
A. ROC plot predicting biopsy proven fibrosis (IFTA > 10%) in protocol biopsies from the AUSCAD cohort. Yellow = model trained on transplant fibrosis dataset (n = 14) from the PROMAD atlas. Blue = model trained on transplant fibrosis dataset (n = 3) from the PROMAD atlas. B. Heatmap of fibrosis related gene (from Fig. 3A) expression in minor cell types of the pan-organ allograft dysfunction atlas C. tSNE projection of the cells of the pan-organ allograft dysfunction atlas. Single cells are coloured by minor cell types, as defined by our PROMAD atlas.
