Extended Data Fig. 9: Distinct association patterns of Prevotella with metabolically healthy enriched microbial species among three enterotypes in JD_2014.

a. Histograms are the mean of relative abundance or prevalence (%) of Prevotella and the annotated species in three enterotypes (ETs) in older (aged≥60 years) MCs45 participants. b. Spearman’s rank correlation analysis (two-sided) reveals distinct association patterns between Prevotella and the other top abundant genera within the three ETs in older MCs45 participants. These include Megamonas, Bacteroides, Faecalibacterium, Eubacterium, Roseburia, Ruminococcus, Blautia, Klebsiella, and Escherichia. Asterisks denote a BH-adjusted P < 0.05. c. Spearman’s rank correlation analysis (two-sided) reveals distinct association patterns between Prevotella, P. copri, and the metabolically healthy enriched species within the three ETs in older MCs45 participants. The ‘*’ denotes a BH-adjusted P < 0.05, and the ‘#’ denotes a P < 0.05.