Extended Data Fig. 10: Interaction between host age and metabolic MCs on gut microbial composition in JD_2014. | Nature Medicine

Extended Data Fig. 10: Interaction between host age and metabolic MCs on gut microbial composition in JD_2014.

From: Divergent age-associated and metabolism-associated gut microbiome signatures modulate cardiovascular disease risk

Extended Data Fig. 10

a. Bar plot shows the significant impact of host age on gut microbiota in MCs123 and MCs45 groups, separately, determined by PERMANOVA (one-sided) with Bray-Curtis dissimilarities at the genus level. Asterisks denote a P < 0.05. b. The relationships between age and a set of age-related gut microbial variables, including 55 age-related species, MA, and microbial richness, in MCs subgroups, separately (MCs123 and MCs45, MC1 to MC5). Boxplot shows the absolute Spearman’s rho (two-sided) between MCs123 and MCs45. Boxes represent the interquartile ranges (IQRs) between the first and third quartiles, the center line represents the median, and the whiskers extend 1.5 times the IQR from the top and bottom of the box. Asterisks denote a BH-adjusted P < 0.05. c. Detailed information on health metrics used for stratifying healthy and unhealthy groups in JD_2014. d. The point plot shows the partial Spearman’s correlations (two-sided) between age and age-related gut microbial signatures, including MA, richness, four uniqueness indices, and the relative abundances of genera Bacteroides and Prevotella, within healthy and unhealthy groups. All models were adjusted for sex, educational attainment, smoking status, alcohol drinking status, physical activity, fruit and vegetable intake, and medication use (not for medication-stratified groups). P < 0.05 is considered as statistical significance. Red indicates significant associations in unhealthy groups, green indicates significant associations in healthy groups, and gray indicates non-significant associations. e. PERMANOVA analysis (one-sided) indicates the interaction effect between age and MCs (MCs1 and MCs45) on gut microbial composition. The interaction P values from the unadjusted model (P = 0.01), the model including sex and all environmental factors excluding medications (adjusted Model 1, P = 0.04), and the fully adjusted Model (adjusted Model 1 + medications, P = 0.07) are shown.

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