Extended Data Fig. 2: Stability assessment of the five metabolic MCs in men and women.

a. Heatmaps depict the distribution of all clustering metabolic variables in JD_2010, CM_2010, and JD_2014, stratified by sex. b. Point plots show the Jaccard similarity index for each MC among men and women in JD_2010, CM_2010, and JD_2014. c. PCoA based on Euclidean distance shows the distributions of metabolic variables across the five MCs between men and women. Data are presented as mean values with standard errors. d. Bar plots show the distribution of MCs between men and women. The percentages of each MC within each sex group are presented. Percentages might not sum to 100% because of rounding.