Extended Data Fig. 5: Associations between individual ProtAge APs and each disease studied. | Nature Medicine

Extended Data Fig. 5: Associations between individual ProtAge APs and each disease studied.

From: Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations

Extended Data Fig. 5

For each outcome associated with ProtAgeGap20, a Cox proportional hazards model (n = 45,441) was calculated with all 20 proteins from the ProtAgeGap20 score, adjusted for age, sex (except prostate cancer), ethnicity, Townsend deprivation index, recruitment center, IPAQ activity group, and smoking status. No adjustment was made for multiple comparisons. In a), the association between each protein and incident disease is colored by z-score, with z-scores for associations with p-value ≥ 0.05 set to 0. In b), the importance of each protein with p < 0.05 is shown as a relative contribution. Relative contribution for each disease is calculated by scaling z-score for significant proteins such that they add to 1. APs: aging-related proteins; ProtAgeGap20: proteomic age gap from the 20-protein model.

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