Extended Data Fig. 1: Stability of ProtAge protein associations with age across three time points.

Comparison of betas for the association between age and each of the 149 ProtAge APs with repeat measurements available during baseline and two follow-up imaging visits (n = 1,085). a) Comparison of betas for the association between age and each of the 149 ProtAge APs during baseline and the 2014+ follow-up imaging visit. b) Comparison of betas for the association between each of these 149 ProtAge APs and age during baseline and the 2019+ imaging visit. c) Comparison of betas for the association between each of the 149 ProtAge APs and age during the 2014+ imaging visit and during the 2019+ imaging visit. Shown in each plot are the Pearson correlation coefficient (r), p-value for the correlation, and the model slope (λ). APs: aging-related proteins.