Fig. 2: Impact of doxy-PEP use on the gut resistome for DNA-seq samples and RNA-seq samples. | Nature Medicine

Fig. 2: Impact of doxy-PEP use on the gut resistome for DNA-seq samples and RNA-seq samples.

From: Impact of doxycycline post-exposure prophylaxis for sexually transmitted infections on the gut microbiome and antimicrobial resistome

Fig. 2

a–d, Normalized resistome mass (a,b) and resistome alpha diversity (Shannon diversity index) (c,d) for DP versus SOC participants (DNA-seq: n = 127; RNA-seq: n = 86). e,f, Resistome beta diversity (Bray–Curtis index) in DP versus SOC participants at 6 months (DNA-seq: n = 69; RNA-seq: n = 60). P values were calculated using the two-sided Wilcoxon rank-sum test and adjusted for multiple comparisons (a–d). Two-sided PERMANOVA P values for beta diversity were calculated and adjusted for multiple comparisons (e,f). Box plot elements include a center line (median), box limits (upper and lower quartiles) and whiskers (1.5× IQR).

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