Fig. 5: Impact of doxy-PEP use on tetracycline ARGs in sets of paired DNA-seq samples and paired RNA-seq samples. | Nature Medicine

Fig. 5: Impact of doxy-PEP use on tetracycline ARGs in sets of paired DNA-seq samples and paired RNA-seq samples.

From: Impact of doxycycline post-exposure prophylaxis for sexually transmitted infections on the gut microbiome and antimicrobial resistome

Fig. 5

Tetracycline ARG richness (a,b) and the tetracycline ARG proportional mass within the resistome (c,d) were compared between SOC and DP arms by visit and over time (DNA-seq: n = 38 paired sample sets; RNA-seq: n = 16 paired sample sets). e, Heatmap of tetracycline ARGs detected by DNA-seq in paired samples (day-0 and month-6 samples) for the SOC and DP arms (n = 38 paired sample sets). P values were calculated using the two-sided Wilcoxon signed-rank test for paired samples and adjusted for multiple comparisons. Box plot elements include a center line (median), box limits (upper and lower quartiles) and whiskers (1.5× IQR). D0, day 0; M6, month 6.

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