Fig. 3: Comprehensive clinical-methylomic nomogram that predicted BM development from LUAD tissues.
From: Prediction of brain metastasis development with DNA methylation signatures
a, Point calculator diagram assigning point values to methylome and TNM scores, followed by the nomogram that uses total summed point values to derive composite probabilities of 5-year BM development. b, Kaplan–Meier plot and log-rank test of high-risk and low-risk nomogram scores, based on the median, demonstrating in the independent validation dataset that high-risk scores capture most of the early BM events plus BM that occurs within 5 years, while most low-risk scores occur in patients who do not develop BM early or within 5 years. c, Results of the univariable Cox proportional hazards model using nomogram scores demonstrating the significantly increased BM risk with increasing nomogram score (n = 60). The box with the whiskers displays the HR and 95% CI. d, Time-dependent mean AUROC with associated 95% CI in the validation cohort, using a bootstrap resampling approach to derive nomogram scores, showing accurate differentiation of patients who developed BM within 5 years (n = 42). The box with the whiskers displays the AUROC and 95% CI. * denotes a significant P value.
