Fig. 4: Heatmap and unsupervised cluster analysis.

Heatmap and unsupervised cluster analysis (Euclidean, complete) in the full cohort (n = 351) of cognitive tasks shaded by correlation (Spearman), including cognition (accuracy and inverse RT), clinical variables, biomarkers and neuroimaging. *P < 0.05, **P < 0.01, ***P < 0.001 two-tailed Spearman correlation adjusted for multiple comparisons (37 ×3 7 matrix, n = 1,369) using the FDR approach. ACB, anticholinergic burden; BIB, brain injury marker; COG, cognitive task; OFC, orbitofrontal cortex; PHG, parahippocampal gyrus; SR, self-report; STG, superior temporal gyrus.