Fig. 2: Overview of concordance for the Rapid-CNS2 cohort.
a, Archival samples. b, Diagnostic samples. Bars indicate on-target coverage, sequencing time and the percentage of SNVs that were recovered in Rapid-CNS2 data from their corresponding NGS data. Site and device blocks indicate site of sequencing (University Hospital Heidelberg or University of Nottingham) and the device that sequencing was run on. NGS and methylation array blocks indicate the availability of corresponding conventional data. Following blocks indicate concordance with available matched conventional data. Methylation classification displays concordance levels of the Rapid-CNS2 ad hoc classifier with corresponding methylation array-based classification. Methylation class indicates the ‘ground truth’ or inferred methylation class. MGMTp shows concordance of MGMT promoter methylation status with matched conventional data.
