Extended Data Table 1 AN1792 cohort demographics
From: Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease
- Aβ, amyloid-beta; AD, Alzheimer’s disease; ADRC, Alzheimer’s Disease Research Center; APOE, apolipoprotein E; CAA, cerebral amyloid angiopathy; capCAA, capillary cerebral amyloid angiopathy; CERAD, Consortium to Establish a Registry for Alzheimer's Disease, classification of neuritic plaque pathology in AD; CVA, cerebrovascular accident; DVT, deep vein thrombosis; FTLD-TDP, frontotemporal lobar degeneration with TAR DNA-binding protein 43 pathology; LBD, Lewy body disease, neocortical (diffuse); PSP, progressive supranuclear palsy; VBI, vascular brain injury; FCX, frontal cortex; iAD-lim, immunized with limited Aβ clearance; iAD-ext, immunized with extensive Aβ clearance; m/f, male/female; NA, not available/applicable; nAD, non-immunized Alzheimer’s disease; NND, non-neurologic disease; TDP-43, TAR DNA-binding protein 43; Anti-AN1792 mean titre, mean antibody titre against AN1792; Braak stages, classification of tau pathology in AD; APOE allele copy number, number of APOE-ε4 alleles; duration of dementia, duration in years; last known dementia status, severity at last assessment; survival time from first immunization, months from first AN1792 dose to death. Method 1: Analysis of plaque removal was scored semi-quantitatively in frontal, temporal, parietal and occipital neocortex as: very extensive (that is nearly complete clearance of plaques) = +++; intermediate (that is multiple and/or extensive plaque-free foci each involving a >1 cm length of cortical ribbon) = ++; very limited (that is single and/or small plaque-free foci each involving each involving a <1 cm length of cortical ribbon) = +; no evidence of plaque removal = −. Method 2: Quantification of amyloid-β plaques in coronal hemisphere sections (score out of 3). *LBD with marked capillary angiopathy but no plaques, possibly reflecting clearance of diffuse plaques. Alzheimer's disease neuropathological change: A = amyloid-β plaque score; B = neurofibrillary tangle stage; C = neuritic plaque score according to National Institute on Aging-Alzheimer’s Association guidelines (Hyman et al., 2012).
