Extended Data Fig. 7: Correlation between imaging findings and histopathology.

An autopsy case: a male subject with progressive MS, aged 44.5 years with a disease duration of 15 years at death. a, FLAIR image 7.5 years before death showing large lesions. b, T1 image 6 years before death overlaid with PET showing high PK11195 signal at the edge of the lesions. c, FLAIR image 2 years before death showing further enlargement of the lesions with prominent atrophy. The arrows and their colors refer to d and g. d and g, Gross anatomy. The boxed areas were analyzed by histology. e and f, The lesion area indicated by the orange rectangle in d stained for the myelin marker MBP (e) and the myeloid cell marker HLA-DR (f). h and I, The lesion area indicated by the blue rectangle in g stained for MBP (h) and HLA-DR (i). Dashed lines in e,f, and h,i indicate the lesion border or the rim border, respectively. Scale bar for e,f,h,i: 3 mm.