Extended Data Fig. 4: Comparison of BRL and mixed lesions.
a to a, Comparison of densities of CD68+ (a), HLA-DR+ (b), IBA1+ (c), TSPO+ (d), iNOS+ (e) 163+ (f) CD206+ (g) and TMEM119+ (h) cells in NAWM, rims and lesion centers of BRL and mixed lesions. i to k, No differences in the densities of CD79a+ B cells (i), CD3+ T cells (j), GFAP+ astrocytes (k) and TPPP/p25+oligodendrocytes (l) in the rims of BRL. m to w, Stratification of BRL and mixed lesions with respect to the presence or absence of iron depositions in the rims of these lesions. Densities of CD68+ (m), HLADR+ (n), IBA1+ (o), TSPO+ (p), iNOS+ (q), CD163+ (r), CD206+ (s), TMEM119+ (t), CD3+ (u), CD79a+ (v) and TPPP/p25+ (w) cells a to w: violin plots, p values were determined depending on normality by Kruskal-Wallis (one-way ANOVA) and Dunn’s multiple comparison test (a, c to j, i,r to v) or Brown-Forsythe and Welch ANOVA test (one-way ANOVA) and Dunnett’s correction for multiple comparisons (b,c, k, m to o and w). * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001.
