Extended Data Fig. 2: Robust predictions of gut-microbiome associated metabolites (n = 197). | Nature Medicine

Extended Data Fig. 2: Robust predictions of gut-microbiome associated metabolites (n = 197).

From: Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes

Extended Data Fig. 2

A-C. Explained variance in microbial metabolites attributed to metagenomic species (MGSs) as assessed by reference-free canopy clustering versus reference-based Kraken 2 (A), lineage-specific marker genes based MetaPhlAn 4 (B), and functional KEGG orthologies (C), respectively. D. Comparison of explained variance in microbial metabolites by the gut microbiome using GBDT versus random forest algorithms. E. Explained variance in microbial metabolites by the gut microbiome in the Swedish versus UK twins cohorts. Two-sided Pearson correlation analyses were performed with raw p values reported for results in A-E.

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