Extended Data Fig. 4: Association between PREDICT T1D microRNAs and autoantibody expression.
From: A microRNA-based dynamic risk score for type 1 diabetes
A sub-analysis was carried out to assess correlation between autoantibody levels (IA2A, GADA, ZnT8R and ZnT8W) and PREDICT T1D microRNA abundance for participants from DNK, wherein autoantibody measurements for a subset of siblings and cases (T1D) were available. All statistically significant two-sided spearman correlations (P < 0.05) are indicated with a red (positive correlation) or blue (negative correlation) fill colour; a white fill represents no significant correlation. The correlation coefficient is presented within the correlation matrix as per the colour shade legend (right). Data represent siblings (n = 168) who had a first-degree relative (parent and/or sibling) with T1D and n = 96 individuals who were clinically diagnosed with T1D.
