Extended Data Fig. 5: Inter-individual and bulk LHb two-photon data.
From: A distinct hypothalamus–habenula circuit governs risk preference
a, Mean calcium transients (smoothed) for individual mice for all decisive trials sorted for mean activity in the DP. b, Quantification of two-photon bulk activity during the DP for present preferred (violet) and non-preferred (gray) choice trials (n = 12 mice). Line colors indicate individual risk preference (risk averse (cyan), risk neutral (black), risk prone (magenta), p = 0.0425). Two-photon bulk data were achieved from drawing a single region of interest (ROI) containing all recorded cells across the entire field of view (FOV). c, Ratio of LHb ΔF/F integrals during the DP for present risky and safe choice bulk activity correlated with individual risk preference across sessions (n = 12 mice; data are represented as mean ± s.e.m.). d and e, Same as b and c but trials were sorted for choice in the preceding trial (p = 0.0049).Two-sided Wilcoxon-signed rank test.
