Extended Data Fig. 2: Risk preference is independent of motivation, decisiveness, anxiety or sex.
From: A distinct hypothalamus–habenula circuit governs risk preference
a, Fraction of engaged trials for all risk averse (cyan, n = 32) and risk prone (magenta, n = 15) mice. Open circles indicate fractions of engaged trials (decisive and indecisive) from all trials an animal could engaged in (200 or 300 per session in 14 sessions, 2800 or 4200 trials for each mouse; p = 0.1076). b, Fraction of decisive trials measured as the fraction of all trials an animal could engage in subtracted by the number of indecisive trials (p = 0.2178). Results from plus maze test of animals after completion of two-alternative choice task. Comparison of risk averse (cyan, n = 21) and risk prone (magenta, n = 4) mice in open field (c-f; p = 0.9188, p = 0.7596, p = 0.3948, p = 0.9729), light-dark (g-j; p = 0.9729, p = 0.3958, p = 0.3591, p = 0.5633), and elevated plus maze test (k-o; p = 0.4756, p = 0.9188, p = 1.0, p = 0.5187, p = 0.7084). Fraction risky (p, p = 0.6207), engaged (q, p = 0.1564), and decisive (r, p = 0.8421) trials for male (blue, n = 10) and female (red, n = 9) mice (based on 600 trials across 3 sessions). Comparison of the same animals in open field (s-v; p = 0.0338, p = 0.1063, p = 0.8872, p = 0.4117), light-dark (w-z; p = 0.1834, p = 0.0253, p = 0.0219, p = 0.8650), and elevated plus maze test (aa-ee; p = 0.4791, p = 1.0, p = 0.3802, p = 0.3502, p = 0.1484).*p < 0.05, two-sided Wilcoxon rank sum test. For box plots, the median is indicated by the central line; 25th and 75th percentiles are indicated by the box and maximum/minimum values excluding outliers are indicated by the whiskers.
