Extended Data Fig. 2: Behavioral assessment across different treatment groups in P301S/E4 mice.
a, Percentage freezing quantified during tone–shock/pairing (males: nVeh = 19, nZol ZT13 = 14, nLem ZT3 = 12, nLem ZT13 = 13, two-way ANOVA, Dunnett’s post hoc test; females: nVeh = 17, nLem ZT3 = 15, nLem ZT13 = 9, two-way ANOVA, Dunnett’s post hoc test); b, contextual conditioning (males: nVeh = 19, nZol ZT13 = 14, nLem ZT3 = 12, nLem ZT13 = 13, two-way ANOVA, Dunnett’s post hoc test; females: nVeh = 17, nLem ZT3 = 15, nLem ZT13 = 9, two-way ANOVA, Dunnett’s post hoc test); c, auditory cue conditioning (males: nVeh = 19, nZol ZT13 = 14, nLem ZT3 = 9, nLem ZT13 = 13, two-way ANOVA, Dunnett’s post hoc test; females: nVeh = 17, nLem ZT3 = 15, nLem ZT13 = 9, two-way ANOVA, Dunnett’s post hoc test). d, Percentage alternation rate quantified in Y-maze alternation test (males: nVeh = 19, nZol ZT13 = 14, nLem ZT3 = 12, nLem ZT13 = 13, one-way ANOVA, Dunnett’s post hoc test; females: nVeh = 17, nLem ZT3 = 14, nLem ZT13 = 9, one-way ANOVA). For detailed statistical information, see Supplementary Table 1. Data represent mean ± s.e.m. in biological replicates. *P < 0.05, and ** P< 0.01.
