Extended Data Fig. 10: Sequence conservation of the yeast ceramide synthase subunits Lac1 and Lip1. | Nature Structural & Molecular Biology

Extended Data Fig. 10: Sequence conservation of the yeast ceramide synthase subunits Lac1 and Lip1.

From: Structure of the yeast ceramide synthase

Extended Data Fig. 10

A Clustal-based multiple-sequence alignment (MSA) of Lac1 Saccharomyces cerevisiae (P28496), Lag1 Arabidopsis thaliana (Q9LDF2), CS hyl-1 Caenorhabditis elegans (G5ED45), TLC ___domain containing protein Caenorhabditis elegans (X5LPS5), CS Dictyostelium discoideum (Q54S87), CS4 Mus musculus (Q9D6J1), CS2-like Danio rerio (E7F9X7), CS2 Homo sapiens (Q96G23), CS1 Homo sapiens (P27544). Sequences are color coded by conservation with a cut-off at 30 %. Catalytic residues are highlighted in red. Sequences were selected by highest sequence identity hits from protein BLAST of selected model organisms. B Sequence of Saccharomyces cerevisiae Lip1 (Q03579). Non-resolvable residues from cryo-EM are marked in light gray. MSAs were prepared with Jalview3.

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