Table 1 Characteristics of TANEC infants.

From: RBC transfusion and necrotizing enterocolitis in very preterm infants: a multicenter observational study

 

TANEC (N = 149)

No-NEC (N = 15,213)

UNTA-NEC (N = 795)

P values

TANEC vs No-NEC

TANEC vs UNTA-NEC

Maternal age (median, IQR)

30 (28–34)

31 (28–34)

31 (28–34)

0.587

0.905

Cesarean delivery (n, %)

78/149 (52.4)

8900/15,167 (59.7)

482/794 (60.7)

0.119

0.057

Gestational age, weeks (median, IQR)

28.9(27.1–30.4)

29.4(28–30.9)

29.9 (28.3–31)

0.003

 < 0.001

Gestational age weeks (n, %)

 < 26

14/149 (9.4)

945/15,213 (6.2)

47/795(5.9)

0.043

0.052

 26–28

43/149 (28.9)

3137/15,213 (20.)

130/795(16.4)

0.017

 < 0.001

 29–30

45/149 (30.2)

5545/15,213 (36.5)

286/795 (36.0)

0.518

0.543

 30–32

43/149 (28.9)

4570/15,213 (30.0)

274/795 (34.5)

0.828

0.538

 > 32

4/149(2.7)

1016/15,213 (6.7)

58/795 (7.3)

  

Birth weight, grams (median, IQR)

1140 (950–1310)

1200 (1004–1400)

1240 (1030–1450)

0.001

 < 0.001

Birth weight, grams (n, %)

 < 1000

47/149 (31.5)

3343/15,213(22.0)

160/795 (20.1)

0.002

 < 0.001

 1000–1500

87/149 (58.4)

9453/15,213 (62.1)

482/795 (60.6)

0.936

0.754

 ≥ 1500

15/149 (10.1)

2417/15,213 (15.9)

153/795 (19.3)

  

Male gender (n, %)

84/149 (56.4)

8597/15,207 (56.5)

464/794 (58.4)

0.984

0.697

SGA (n, %)

23/149 (15.4)

2270/15,133 (15.0)

127/794 (16.0)

0.881

0.866

Inborn (n, %)

103/149 (69.1)

9392/15,213 (61.7)

474/795 (59.6)

0.066

0.030

Placental transfusion (n, %)

59/149 (39.6)

4547/15,213 (29.9)

276/795 (34.7)

0.011

0.254

Endotracheal incubation during resuscitation (n, %)

54/149 (36.2)

4876/15,213 (32.1)

176/795 (22.1)

0.276

 < 0.001

Low 5-min Apgar score (n %)

35/149 (23.5)

3367/15,213 (22.1)

122/795 (15.4)

0.691

0.014

Age at first feed in days ≤ 3 (n, %)

110/149 (73.8)

9862/15,213 (64.8)

494/795 (62.1)

0.023

0.006

Duration of antibiotic therapy in 1st 7 days of life in days > 4 (n, %)

101/149 (67.8)

9888/15,213 (65.0)

443/795 (55.7)

0.478

0.007

PDA (n %)

86/149 (58.5)

7352/15,213 (49.3)

396/795 (49.8)

0.026

0.083

PDA (required treatment) (n %)

39/149 (26.2)

3013/15,213 (19.8)

160/795 (20.1)

0.057

0.101

  1. NEC necrotizing enterocolitis, No-NEC infants without NEC, UNTA-NEC preterm infants with NEC prior to all transfusion or NEC occurred beyond 2 days after transfusion, TANEC occurred within 2 days after transfusion, SGA small for gestational age.
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