Figure 9 | Scientific Reports

Figure 9

From: Investigating the role of senescence biomarkers in colorectal cancer heterogeneity by bulk and single-cell RNA sequencing

Figure 9

PPI network of genes in senescence-related model. (a) PPI network of genes in model. Red line—indicates the presence of fusion evidence; Green line: neighborhood evidence; Blue line: cooccurrence evidence; Purple line: experimental evidence; Yellow line: text-mining evidence; Light blue line: database evidence; Black line: co-expression evidence. (b) Hub genes identified from genes in model. (c) Relationship between hub gene expression levels and immune cell infiltration. (d–i) Validation of expression levels of hub genes between normal cell line (NCM-460) and CRC cell lines (HCT 116, HT-29) by RT-qPCR. (d) CXCL13. (e) MMP12. (f) CXCL1. (g) CXCL9. (h) IL7R. (i) MMP3.

Back to article page