Fig. 1

(A)Time from initial diagnosis to acquisition of BRAF variants.(B) The TKIs sequences before acquisition of BRAF variants: 1, 2, and 3 indicate the first-generation TKIs, second-generation TKIs, and third-generation TKIs, respectively.(C) the distribution of BRAF mutations.(D) The mutation counts in the overall population and patients of different BRAF subtypes.