Fig. 4

Anti-PD-1/PD-L1-related severe cardiac adverse events. ALL figures was generated by Microsoft Office Excel 365. (A) The bar plot shows the statistics of the top 28 PTs of co-reported adverse events. The colour indicates the SOC of the corresponding PT. The percentage values in the figure represent the proportion of cases with such adverse events out of the total anti-PD-1/PD-L1-related severe cardiac adverse event cases with co-reported adverse events. (B) The bar plot shows the SOC statistics regarding PTs of co-reported adverse events. The percentage values in the figure represent the proportion of cases with such adverse events out of the total anti-PD-1/PD-L1-related severe cardiac adverse event cases with co-reported adverse events. (C) The forest plot shows the multifactor logistic regression analysis results regarding the factors influencing anti-PD-1/PD-L1-related severe cardiac adverse events. The variables represented in red and bold have statistical significance. ACEI/ARB: angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, AEs: adverse events, Chemo: chemotherapy, NSAIDs: non-steroidal anti-inflammatory drugs, OR: odds ratio, PPI: proton pump inhibitor, PT: preferred term, SOC: systemic organ class, TTD: targeted therapeutic drugs.