Fig. 6
Evaluation of the association between anti-PD-1/PD-L1-related severe cAEs and gene-related factors. ALL figures was generated by Microsoft Office Excel 365. (A) Pathway enrichment of the top thirty genes significantly correlated with anti-PD-1/PD-L1-related severe cAEs across multiple cancer types. (B) Linear correlation model between LRP3 expression and anti-PD-1/PD-L1-related severe cAEs. (C) Comparison of performance of bivariate models in predicting anti-PD-1/PD-L1-related severe cAEs for all combinations of the top ten anti-PD-1/PD-L1-related severe cAEs PRR significantly correlated genes. Spearman correlation (Rs) was calculated between the predicted and observed anti-PD-1/PD-L1-related severe cAEs PRR. The shade of the square indicates the Rs, and the size indicates the significance of the log-likelihood ratio test. (D) The combined effect of LRP3 and TRAV27 bivariate model (Spearman correlation, Rs = 0.88, FDR = 4.05 × 10− 10). The equation of the bivariate regression model is 0.727 + 0.538 × LRP3 + 1.399 × TRAV27. PRR: proportional reporting ratio, FDR: false discovery rate, ACC: adrenocortical carcinoma, BLCA: bladder urothelial carcinoma, BRCA: breast invasive carcinoma, CESC: cervical squamous cell carcinoma and endocervical adenocarcinoma, CHOL: cholangiocarcinoma, COAD: colon adenocarcinoma, ESCA: esophageal carcinoma, FDR: false discovery rate, GBM: glioblastoma multiforme, HNSC: head and neck squamous cell carcinoma, KICH: Kidney Chromophobe, KIRC: kidney renal clear cell carcinoma, KIRP: kidney renal papillary cell carcinoma, LGG: brain lower-grade glioma, LIHC: liver hepatocellular carcinoma, LRP3: low-density lipoprotein receptor-related protein 3, LUAD: lung adenocarcinoma, LUSC: lung squamous cell carcinoma, MESO: mesothelioma, OV: ovarian serous cystadenocarcinoma, PAAD: pancreatic adenocarcinoma, PRAD: prostate adenocarcinoma, PRR: proportional reporting ratio, READ: rectum adenocarcinoma, SARC: sarcoma, SKCM: skin cutaneous melanoma, STAD: stomach adenocarcinoma, THCA: thyroid carcinoma, THYM: Thymoma, T TRAV27: Cell Receptor Alpha Variable 27, UVM: uveal melanoma..
