Fig. 6
From: The senolytic drug ABT-263 accelerates ovarian aging in older female mice
Effects of ABT-263 treatment on the steroidogenic gene expression of ovarian stromal cells in aged mice. (A) Representative fluorescence images of ovarian sections stained with anti-Cyp11a1 antibody. (B) Statistical analysis of the percentage of Cyp11a1-positive cells in the ovarian stroma. n = 3 in the Y group, n = 6 in the O group, and n = 4 in the A group. (C) Representative fluorescence images of ovarian sections stained with anti-SF1 antibody. (D) Statistical analysis of the percentage of SF1-positive cells in the ovarian stroma. n = 3 in the Y group, n = 6 in the O group, and n = 4 in the A group. qPCR analysis of the expression of Cyp11a1 and StAR on ovaries among groups, ΔCT value of (E) Cyp11a1 and (F) StAR, the relative expression of (G) Cyp11a1 mRNA and (H) StAR mRNA. n = 6 in each group. Y: young group; O: old group; A: old group treated with ABT-263. CL: corpus luteum; GF: graafian follicle; SC: stromal cell; TC: theca cell. Compared with the Y group: *P < 0.05; Compared with the O group: #P < 0.05.
