Fig. 4
From: CISD3 is a prognostic biomarker and therapeutic target in pan-cancer
Analysis of CISD3 with genomic instability and epigenetic modifications. (A) Pie chart showing the percentage of different types of CISD3 CNV in pan-cancer. (B) Box plot of CISD3 mRNA expression in different types of CNV alterations in pan-cancer. (C) Bubble chart summarizing the survival differences between CISD3 genomic CNV and wild-type. The color of the bubbles ranges from blue to red, representing hazard ratios from low to high, and the size of the bubbles is positively correlated with the significance of the Logrank P value. Black outline indicates Logrank P value ≤ 0.05. (D) Kaplan-Meier curves evaluating the correlation of CISD3 CNV with OS in four types of cancer. (E) Lollipop chart showing the correlation between CISD3 and HRD in pan-cancer. (F) Radar chart showing the correlation between CISD3 and neoantigens in pan-cancer. (G) Box plot of methylation differences between tumor samples and normal samples for CISD3. (H) Bubble chart showing the correlation between CISD3 mRNA expression and methylation. (I) Kaplan-Meier curves evaluating OS differences between high and low methylation groups of CISD3 in four types of cancer. (J) Heatmap showing the correlation between CISD3 expression and mRNA modification methylation regulatory factors in pan-cancer. *P < 0.05, **P < 0.01, ***P < 0.001.
