Table 3 Complications, mental health, adverse drug events, and opioid use outcomes during index hospitalization and first 30 days.
From: Polypharmacy in elective lumbar spinal surgery for degenerative conditions with 24-month follow-up
Complications | All | Fusion with or without decompression | Decompression without fusion | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
No Polypharmacy (n = 37,682) | Polypharmacy (n = 80,752) | p-value | No Polypharmacy (n = 16,676) | Polypharmacy (n = 44,411) | p-value | No Polypharmacy (n = 30,909) | Polypharmacy (n = 64,748) | p-value | ||
Index Hospital | Acute kidney injury, % | 1% | 1% | Â | 1% | 1% | Â | 1% | 1% | 0.0008 |
Surgical Site Infection, % | 0% | 1% | 0.0118 | 0% | 0% | Â | 1% | 1% | ||
Cardiac Arrest, % | 0% | 0% | Â | 0% | 0% | Â | 0% | 0% | ||
Deep Vein Thrombosis, % | 0% | 0% | Â | 0% | 0% | Â | 0% | 0% | ||
Myocardial Infarction, % | 0% | 0% | Â | 0% | 0% | Â | 0% | 0% | ||
Pneumonia, % | 4% | 5% | < 0.0001 | 5% | 5% |  | 4% | 5% | ||
Pulmonary Embolism, % | 0% | 0% | Â | 0% | 0% | Â | 0% | 0% | ||
Stroke, % | 0% | 0% | Â | 0% | 0% | Â | 0% | 0% | ||
Wound Dehiscence % | 0% | 0% | Â | 0% | 0% | Â | 0% | 0% | ||
Urinary Tract Infection % | 2% | 2% | Â | 2% | 2% | Â | 2% | 2% | ||
At least one of the above, % | 16% | 19% | < 0.0001 | 17% | 20% | < 0.0001 | 14% | 17% | < 0.0001 | |
1-month outcomes | Acute kidney injury, % | 0% | 1% | 0.0219 | 1% | 1% |  | 0% | 0% | < 0.0001 |
Surgical Site Infection, % | 4% | 6% | < 0.0001 | 4% | 7% | < 0.0001 | 4% | 6% | ||
Cardiac Arrest, % | 0% | 0% | Â | 0% | 0% | Â | 0% | 0% | ||
Deep Vein Thrombosis, % | 2% | 3% | < 0.0001 | 2% | 3% | 0.0044 | 1% | 1% | ||
Myocardial Infarction, % | 0% | 0% | Â | 0% | 0% | Â | 0% | 0% | ||
Pneumonia, % | 6% | 7% | 0.0009 | 6% | 7% | 0.0379 | 5% | 6% | 0.0013 | |
Pulmonary Embolism, % | 1% | 1% | Â | 1% | 1% | Â | 1% | 1% | ||
Stroke, % | 1% | 1% | Â | 0% | 0% | Â | 0% | 1% | 0.0047 | |
Wound Dehiscence % | 1% | 2% | < 0.0001 | 1% | 2% | 0.0001 | 1% | 2% | >0.0007 | |
Urinary Tract Infection % | 3% | 4% | < 0.0001 | 3% | 4% | 0.0038 | 2% | 3% | < 0.0001 | |
At least one of the above, % | 17% | 24% | < 0.0001 | 19% | 24% | < 0.0001 | 14% | 20% | < 0.0001 | |
