Fig. 7 | Scientific Reports

Fig. 7

From: CHD1L accelated the progression of cutaneous squamous cell carcinoma via promoting PI3K/PD-L1 signaling pathway induced M2 polarization of TAMs

Fig. 7

In the hypoxic environment of cutaneous squamous cell carcinoma, CHD1L can promote the secretion of PD-L1 by cancer cells, thus promoting the activation of the ERK/AKT/mTOR signaling pathway and M2 polarization in tumor-associated macrophages, inhibiting M1 polarization and leading to the proliferation, migration, invasion, and angiogenesis of cutaneous squamous cell carcinoma cells.

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