Fig. 4

Relationship between IS score and genomic events in colon cancer patients. (A) The correlation between ISs and TMB scores. (B) The figure depicts the frequency of gene mutations in TCGA-COAD. (C) The analysis presents the correlation between the expression of high mutation frequency genes and ISs. (D) The analysis demonstrates the correlation between CNV scores and ISs. (E) The disparity in gene mutation frequency between HIS and LIS patients. (F–H) The comparison focuses on the gene mutation sites between HIS and LIS patients, specifically analyzing BRAF, KMT2B, and AHNAK2. (I,J) The analysis compares chromosomal amplifications and deletions between LIS and HIS patients.