Fig. 4 | Scientific Reports

Fig. 4

From: A bitopic mTORC inhibitor reverses phenotypes in a tuberous sclerosis complex model

Fig. 4

Rapalink-1 Reduces Cell Size. A-D) 20× images of GFP (blue, A), RFP (red, B), pS6 (green, C), and composite (D) in Tsc2mut/mut P90 control brains. E-H) 20× images of GFP (blue, E), RFP (red, F), pS6 (green, G), and composite (H) in Tsc2mut/mut P90 Rapalink-1 (3 mg/kg) brains. I, J) Images from D and H magnified 400% showing examples of giant cells. K) Quantification of neuron soma size relative to controls. Data is represented as mean ± SEM. Scale bar = 75 μm. ****=p < 0.0001.

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