Fig. 6
Early detection of E. coli. (a) The log-difference of the spectral weights in three frequency bands, highlighting only the data for DLD microclusters treated with PBS and those infected by 100 cfu/mL E. coli. The bands and error bars indicate the standard error. The spectral shift observed from the infected microclusters deviates from that observed from the PBS treated microclusters outside the standard error range for the mid-frequency band almost immediately upon infection, reaching a 3 sigma difference as early as 2 hours (red vertical line), and by 7 hours for high-frequency band (blue vertical line). These trends demonstrate the early detection of the effects low dose infection. (b) The tissue-response spectrograms corresponding to the two conditions. Color scale shows the log difference of spectral weight with respect to the baseline. Black line indicates the time of infection. Each of the contour lines are separated by 0.2 units of \(\Delta \log (S)\) on the color scale. The upper panel (DLD + PBS) is the average of 19 replicates, and the lower panel is the average of 8 replicates.
