Fig. 5 | Scientific Reports

Fig. 5

From: Integrative in Silico and in vitro validation suggest LINC00963 and SNHG15 as candidate biomarkers for coronary artery disease

Fig. 5

SNHG15 and LINC00963 expression were validated in CAD patients versus healthy controls using qRT-PCR. (A) qRT-PCR analysis revealed a significant upregulation of SNHG15 expression in CAD patients (n = 50) compared to healthy controls (n = 50) (P < 0.001; Mann–Whitney U test). (B) Heatmap visualization of SNHG15 expression across individual samples, showing consistent elevation in the CAD group. (C) LINC00963 expression was also significantly higher in CAD patients than in controls (P < 0.001). (D) Heatmap of LINC00963 expression confirms the strong upregulation pattern in CAD individuals. Data are presented as mean ± SD. *** indicates statistical significance (P < 0.001). All reactions were performed in biological duplicates and technical triplicates. These results support the potential of SNHG15 and LINC00963 as diagnostic biomarkers in CAD.

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