Table 1 Ventilation strategy.

From: Lung protective ventilation guided by driving pressure improves pulmonary outcomes in heart transplantation

Initial ventilation parameters

Plan A

Plan B

Mode

Pressure regulated volume control

Tidal volume - mL

6 mL/Kg PBW*

(not exceed 8mL/Kg PBW)

6 mL/Kg PBW*

(not exceed 8mL/Kg PBW)

Respiratory rate - cycle per minute

10

10

Inspiratory/expiratory ratio

1:1.5**

Inspiratory oxygen fraction - %

50

PEEP setting rules

Lowest driving pressure

(not exceed 8 cm H2O)

Optimal oxygenation function

(not exceed 8 cm H2O)

On-pump Ventilation

Tidal volume: 4 mL/Kg PBW

Respiratory rate: 4 circle per minute

Positive end-expiratory pressure: 4 cm H2O

Inspiratory oxygen fraction: 21%

Ventilatory target

(1) SpO2 ≥ 90% or PaO2 ≥ 60 mm Hg; (2) PaCO2: 35 ~ 50 mm Hg and (3) pH value > 7.20

  1. * PBW (Kg) = [50 (male) or 45.5 (female) + 0.91×(height in centimeter - 152.4)] Kg; **1:2.5 - 1:3 in the patients with chronic obstructive pulmonary disease; PBW: predicted body weight; PEEP: positive end-expiratory pressure; SpO2: peripheric arterial oxygen saturation.
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