Fig. 3

Functional analyses for the DE-FRGs revealed significant associations with various biological processes and pathways. (A) GO enrichment analyses indicated that DE-FRGs were significantly related to "Response to oxygen levels," "Cellular response to chemical stress," "Response to decreased oxygen levels," "Cellular response to oxidative stress," "Response to oxidative stress," and "Negative regulation of inflammatory response" in Biological Processes (BP); “Nuclear matrix” and “Nuclear periphery” in Cellular Components (CC); and "Iron ion binding", "protein phosphatase binding", and “phosphatase binding” in Molecular Functions (MF). (B) KEGG pathway enrichment analyses revealed significant relationships with "Lipid and atherosclerosis," "Fc epsilon RI signaling pathway," "Sphingolipid signaling pathway," "Efferocytosis," "Hepatitis B," "Diabetic cardiomyopathy," and "MAPK signaling pathway."