Fig. 9 | Scientific Reports

Fig. 9

From: OM85 ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting Notch expression and modulating the IFN-γ/IL-4 ratio

Fig. 9

Effects of OM85 on the levels of IFN-γ, IL-4, IFN-γ/IL-4 ratio, and TGF-β1 in BLM-induced pulmonary fibrosis in C57 BALF. OM85 increased the levels of IFN-γ, TGF-β1, and the IFN-γ/IL-4 ratio, while simultaneously decreasing IL-4 in the BALF of IPF induced by BLM. Notably, in healthy mice, OM85 intake promoted the secretion of IFN-γ. Panel A represents IFN-γ, Panel B represents IL-4, Panel C represents the IFN-γ/IL-4 ratio, and Panel D represents TGF-β1. After assessing the normality and calculating the standard deviation (SD) of the sample, ordinary ANOVA tests were performed for IFN-γ, IL-4, the IFN-γ/IL-4 ratio, and TGF-β1. Data represent means ± SD for 10 mice. **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns for P > 0.05.

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