Table 4 Interaction tests for OS, LFS and RR.

From: Total body irradiation versus chemotherapy myeloablative conditioning in B-cell acute lymphoblastic leukaemia patients with first complete remission

 

Risk factors

P-value

HR (95% CI)

OS

Donor type

0.981

0.975 (0.13–7.33)

 

Maintenance after transplantation

0.056

0.247 (0.06–1.04)

 

MRD after 3 cycles of chemotherapy

0.035

5.346(1.13–25.42)

 

TBI

0.017

5.346(1.13–25.42)

 

MRD after 3 cycles of chemotherapy*TBI

0.004

0.076(0.013–0.445)

LFS

Maintenance after transplantation

0.021

0.492 (0.27–0.90)

 

MRD after 3 cycles of chemotherapy

0.018

2.836 (1.19–6.75)

 

TBI

0.113

1.925(0.86–4.33)

 

MRD after 3 cycles of chemotherapy*TBI

0.006

0.216(0.07–0.64)

CIR

MRD after 3 cycles of chemotherapy

0.019

2.960 (1.19–7.35)

 

Tbi

0.950

1.030(0.41–2.60)

 

MRD after 3 cycles of chemotherapy*TBI

0.075

0.320(0.09–1.12)

NRM

Maintenance after transplantation

0.020

0.09(0.01–0.69)

 

Tbi

0.070

6.923(0.85–56.30)

 

MRD after 3 cycles of chemotherapy

0.600

1.922(0.17–21.52)

 

MRD after 3 cycles of chemotherapy*TBI

0.220

0.197(0.01–2.72)