Fig. 13 | Scientific Reports

Fig. 13

From: Remimazolam attenuated lipopolysaccharide-induced behavioral deficits and neuronal injury via activation of the Nrf2 pathway

Fig. 13

Nrf2 inhibitor ML385 reversed the enhancing effect of remimazolam on the mitochondrial membrane potential (MMP). (A) The MMP of cells was measured using a JC-1 assay. The representative images of JC-1 aggregates and JC-1 monomers reflexed the MMP of primary hippocampal neurons. The scale bar represents 200 nm. (B) The ratio of JC-1 aggregates to JC-1 monomers was decreased in neurons administrated with ML385 prior to remimazolam, suggesting that ML385 inhibited the elevation of MMP by remimazolam. Results are shown as means ± SEM (n = 3). *P < 0.05, **P < 0.01, ***P < 0.001.

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