Table 4 Clinical characteristics of patients in different subgroups
From: The role of TERT C228T and KDM6A alterations and TME in NMIBC treated with BCG
|  | Overall (n = 40) | WT (n = 14) | Single-Mut (n = 23) | Co-Mut (n = 3) | p |
|---|---|---|---|---|---|
Age | |||||
 Mean (SD) | 62.30 (9.17) | 61.21 (7.24) | 61.65 (10.01) | 72.33 (5.51) | 0.142 |
 Median [IQR] | 63.00 [55.75, 68.25] | 62.00 [55.25, 65.00] | 62.00 [55.00, 68.50] | 72.00 [69.50, 75.00] | |
Gender | |||||
 Female | 8 (20.0) | 2 (14.3) | 6 (26.1) | 0 (0.0) | 0.457 |
 Male | 32 (80.0) | 12 (85.7) | 17 (73.9) | 3 (100.0) | |
Stage | |||||
 T1 | 34 (85.0) | 12 (85.7) | 19 (82.6) | 3 (100.0) | 0.870 |
 Ta | 5 (12.5) | 2 (14.3) | 3 (13.0) | 0 (0.0) | |
 Tis | 1 (2.5) | 0 (0.0) | 1 (4.3) | 0 (0.0) | |
Grade | |||||
 HG | 34 (85.0) | 12 (85.7) | 19 (82.6) | 3 (100.0) | 0.870 |
Intermediate | 1 (2.5) | 0 (0.0) | 1 (4.3) | 0 (0.0) | |
 LG | 5 (12.5) | 2 (14.3) | 3 (13.0) | 0 (0.0) | |
Tumor percent | |||||
 Mean (SD) | 50.75 (23.90) | 43.57 (19.85) | 50.87 (24.48) | 83.33 (5.77) | 0.028 |
 Median [IQR] | 50.00 [37.50, 80.00] | 40.00 [30.00, 50.00] | 50.00 [40.00, 75.00] | 80.00 [80.00, 85.00] | |
TMB | |||||
 Mean (SD) | 9.47 (6.62) | 9.54 (7.32) | 8.63 (6.02) | 15.62 (6.64) | 0.232 |
 Median [IQR] | 7.98 [4.99, 11.22] | 6.98 [5.24, 11.46] | 7.98 [4.99, 9.97] | 18.94 [13.46, 19.44] | |
HDR score | |||||
 Mean (SD) | 16.38 (15.19) | 15.57 (13.73) | 14.26 (14.14) | 36.33 (20.55) | 0.055 |
 Median [IQR] | 13.00 [4.75, 22.25] | 12.50 [8.00, 19.25] | 12.00 [2.50, 21.00] | 38.00 [26.50, 47.00] | |
Purity | |||||
 Mean (SD) | 0.56 (0.24) | 0.46 (0.25) | 0.59 (0.24) | 0.74 (0.06) | 0.137 |
 Median [IQR] | 0.48 [0.39, 0.80] | 0.44 [0.26, 0.52] | 0.52 [0.41, 0.83] | 0.73 [0.71, 0.76] | |
Ploidy | |||||
 Mean (SD) | 3.20 (2.92) | 2.40 (0.79) | 3.54 (3.68) | 4.31 (2.55) | 0.420 |
 Median [IQR] | 2.00 [1.98, 3.91] | 1.99 [1.97, 2.22] | 2.00 [1.98, 3.95] | 3.90 [2.95, 5.47] | |
nCIN | |||||
 Mean (SD) | 4.12 (4.56) | 3.71 (3.95) | 3.70 (4.44) | 9.33 (6.66) | 0.120 |
 Median [IQR] | 3.00 [1.00, 5.25] | 3.50 [0.25, 4.00] | 2.00 [1.00, 5.00] | 11.00 [6.50, 13.00] | |
