Table 4 Associations of HRD and TMB/MSI status in non-BRCA1/2 HRR mutant cases

From: Homologous recombination deficiency among patients with germline or somatic non-BRCA1/2 homologous recombination repair gene variations

 

Total

HRD+

HRD-

HRD+ rate

p

n = 371

n = 68

n = 303

TMB status

 High

97(26.1%)

11

86

11.3%

0.0384

 Low

274 (73.9%)

57

217

20.8%

 

 TMB value

 

6.1

22.2

-

0.0380

MSI status

 MSI-H

50 (13.5%)

2

48

4.0%

0.0049

 MSS

321 (86.5%)

66

255

20.6%

 
  1. HRD homologous recombination deficiency, TMB tumor mutational burden, MSI microsatellite instability, MSS microsatellite stable.
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