Extended Data Fig. 7: Metabolomics analysis after UPRmt activation during reprogramming. | Nature Metabolism

Extended Data Fig. 7: Metabolomics analysis after UPRmt activation during reprogramming.

From: The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming

Extended Data Fig. 7

a, Metabolomics analysis with CDDOme treatment at day 3 of reprogramming. Orange dots indicate upregulated metabolites, whereas the green dot indicates the lone downregulated metabolite, acetyl-CoA. Unpaired two-tailed student’s t test. b, Heatmap showing the levels of metabolites in control and CDDOme treated cells. Red indicates upregulated metabolites, whereas blue indicates downregulated metabolite.

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