Extended Data Fig. 7: NAD+ pathway analysis in E2-treated aged iWAT. | Nature Aging

Extended Data Fig. 7: NAD+ pathway analysis in E2-treated aged iWAT.

From: Estrogen counteracts age-related decline in beige adipogenesis through the NAMPT-regulated ER stress response

Extended Data Fig. 7

a-c, Upregulated gene ontology (GO) cellular component to E2 (a), upregulated gene ontology (GO) molecular function to E2 (b), and heat map of a list of NAD pathway gene expression (c) (n = 3 per group), by two-tailed unpaired Student’s t-test. d, Quantification of the percentage of RFP+ cells. Animal number: Control Veh (n = 8), Control E2 (n = 6), NAMPT Het Veh (n = 8), NAMPT Het E2 (n = 8). ANOVA summary (Interaction P = 0.997, Condition P < 0.0001, Treatment P < 0.0001, by two way-ANOVA followed by Tukey’s post-hoc test). e, Quantification of the percentage of RFP+ cells that express endogenous UCP1 (n = 6 per group). ANOVA summary (Interaction P = 0.896, Condition P < 0.0001, Treatment P < 0.0001, by two way-ANOVA followed by Tukey’s post-hoc test). Data information: All results are presented as means ± SEM.

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