Extended Data Fig. 1: Human gonadal expression of PNMA2, PNMA3, and PNMA5.
From: The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity
(a) Analysis of uniquely mapping single-cell RNAseq reads for PNMA2, PNMA3, and PNMA5 loci expressed in spermatogonial stem cells (SSC), differentiating spermatogonia (Dif. Sp.), leptotene spermatocytes (Lepto.), grouped zygotene/pachytene/diplotene spermatocytes (ZPD), transitional spermatocytes (Trans.), post-meiotic spermatids (PMS), Leydig cells, Sertoli cells, and macrophages (data from Wang et al.13, N = 8 donors 27–60 years of age). (b) Ovaries from reproductively young (23–29 years, magenta, N = 4) and reproductively old (49–54 years, gray, N = 4) donors were analyzed by single-nuclei RNAseq. Uniquely mapping reads for PNMA2, PNMA3, and PNMA5 loci were assigned to ovarian tissue types based on clustering analysis. Statistical significance was determined by Mann-Whitney test (all comparisons were not significant).
