Fig. 4: OTU networks.
From: Oral and gut microbiome profiles in people with early idiopathic Parkinson’s disease
Microbe-microbe (OTU level) abundance association networks for saliva and stool, and controls and PD cases. The networks in the top row are for stool OTUs in controls (a) and PD cases (b). The networks on the bottom row are for saliva OTUs in controls (d) and PD cases (e). Each point represents an individual OTU, and the size of the point indicates its degree centrality metric. The colored points are for OTUs that have a top 10 degree metric for that specific community (e.g., saliva controls), to highlight the most connected taxa in each network. The color within these points represents the OTU’s taxonomic family. The lines connecting points indicate statistically significant associations in their abundances as determined by the spiec-easi method. The lines are colored and scaled by the absolute value of their correlation coefficient with darker and wider indicating greater correlation magnitude. Solid lines indicate positive correlations, dashed lines indicate negative correlations. The density plots to the right of the networks, for stool (c) and saliva (f) show the distributions of degree centralities for each OTU (node) in the networks. The lines indicate the mean degree for controls (blue) and cases (pink). An asterisk indicates a significant difference in degree between controls and cases, and an “n.s.” indicates no significant difference.
