Fig. 5: Between microbiomes networks.

Microbe-microbe (OTU level) abundance association networks between saliva and stool for controls and PD cases. a The network for controls. b The network for PD cases. Each point represents an individual OTU, and the size of the point indicates its degree centrality metric. The colored points are for OTUs that have a top 10 degree metric for that specific community (e.g., saliva controls), to highlight the most connected taxa in each network. The color within the point represents the OTU’s taxonomic family and its shape indicates whether it was sampled from the saliva (circle) or stool (square). The lines connecting points indicate statistically significant associations in their abundances as determined by the spiec-easi method. The lines are colored and scaled by the absolute value of their correlation coefficient with darker and wider indicating greater correlation magnitude. Solid lines indicate positive correlations, dashed lines indicate negative correlations. c A density plot showing the distributions of degree centralities for each OTU (node) in the networks.