Fig. 6: The Model II separates BMAL1 into cytoplasmic BMAL1 (BMAL1C) and nuclear BMAL1 (BMAL1N).
From: CHRONO regulates the circadian clock via the REV-ERBα – BMAL1 loop
A The schematic of Model II, which considers that CHRONO affects the cytoplasmic/nucleic localization of BMAL1. The dynamic changes of BMAL1 in the cytoplasm and nucleus are described separately in two ordinary differential equations. Further details can be found in Supplementary Text S1. B The bifurcation diagram shows the variation of the period as a function of ksCHRONO. The bifurcation diagram shows the variation of the period as a function of kim,B (C) and kex,B (D) in Model II. In all panels, the red dot on each curve refers to the basal parameter value listed in Table S4, the blue dot refers to the boundaries of the oscillatory ___domain listed in Table S6.
