Fig. 1: Characterization of a novel mycobacterial cytochrome bc inhibitor. | npj Drug Discovery

Fig. 1: Characterization of a novel mycobacterial cytochrome bc inhibitor.

From: Structural and mechanistic study of a novel inhibitor analogue of M. tuberculosis cytochrome bc1:aa3

Fig. 1

a Chemical structures of JNJ-2901, Q203, and TB47. b Inhibitory profile of Q203 and JNJ-2901 on M. tuberculosis H37Rv-ΔcydAB grown in 7H9 medium. MIC50 values Q203: 2.0 ± 0.1, JNJ-2901: 2.5 ± 0.1. c Inhibitory activity of JNJ-2901 on membranes prepared from M. smegmatis wild-type strain, a cytochrome bc knockout strain (ΔqcrCAB) or a cytochrome bd knockout strain (ΔcydAB). d Survival of Mtb H37Rv cytochrome bd knockout strain (ΔcydAB) in an acute mouse model upon exposure with bedaquiline (BDQ) or JNJ-2901 (mpk = milligram per kilogram). Each group contained 6 mice, and error bars indicate standard deviation. e Survival of Mtb H37Rv-ΔcydAB in a chronic mouse model upon exposure with bedaquiline (BDQ) or JNJ-2901 (mpk = milligram per kilogram).

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