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    In this collection, the cancer editorial community of the Nature journals presents the most recently published articles on cancer evolution. The topic is discussed from different angles (preclinical, translational and clinical), and across a range of tumour types.

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    Advances in technology across all areas of science have ushered in an era of big data, providing researchers with unprecedented opportunities to understand how biological systems function and interact. Scientists are now faced with the challenge of developing sophisticated computational tools capable of unravelling these data and uncovering important biological signals. Computational biology will continue to play a key role in facilitating multi-disciplinary collaborations, encouraging data sharing and establishing experimental and analytical standards in the life sciences.

    Image: Sam Rios

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    Translating the power of high-throughput sequencing technologies from the research sphere into the clinic is a current major focus for many health-care providers and researchers, and the power of these technologies is being harnessed to address an increasingly diverse range of problems. Excitingly, real benefits for patients are starting to emerge in areas from infectious disease and cancer, to common and rare genetic disorders and pre-natal testing. At this critical turning point, this collection highlights the breadth of applications of next-generation sequencing technologies in the clinic and the importance of the insights that are being gained through these methods to improve health.

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    This Web Collection presents the results of the RNA Sequencing Quality Control (SEQC) project that sought to evaluate the reproducibility and comparability of high-throughput sequencing of RNA (RNA-seq). Data from several different laboratories are compared and the performance of different sequencing platforms and data analysis approaches are assessed, together with benchmarking against DNA microarrays. Ultimately, these multi-platform, cross-site studies will enable RNA-seq to be applied more broadly in analyzing large cohorts for discovery research and clinical use. This is the latest phase of a collaboration between government, academic and industry researchers as part of the MicroArray Quality Control (MAQC) consortium.We are grateful for the support of our sponsors, the FDA's National Center for Toxicological Research (NCTR/FDA) and the State Key Laboratory of Genetic Engineering (SKLGE) at Fudan University. As always, Nature Research carries sole responsibility for all editorial content.

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    The 2014 Nobel Prize in Chemistry was awarded for the development of superresolution fluorescence microscopy, which enables the imaging of fine biological structures previously thought to be unresolvable using light. This collection of news pieces and articles by the Nobel laureates and their collaborators celebrates this achievement.

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    Transcription activator-like (TAL) effector nucleases have emerged as a powerful tool in genome engineering. Several Nature Biotechnology articles on TAL effector nucleases are brought together in this collection produced with support from Cellectis bioresearch.

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    This supplement collects together reprints of papers from Nature Biotechnology reporting the first formal results of a consortium of over 150 regulatory, industrial and academic scientists that set out to conduct a cross-platform analysis of DNA microarray expression data obtained from two, commercially available RNA samples.