Review Articles

In this Review, the authors discuss the gene–environment interactions including microbial perturbations that shape the early events of inflammatory bowel disease.

In this Review, Boeckxstaens and colleagues discuss the roles of neuron-associated macrophages in development and inflammation of the gut.

In this Review, the authors discuss the latest in skin immunology research with a special focus on the role of skin-resident T cells.

Tak Mak and colleagues review the role of cholinergic T cells in the tumor immune microenvironment.

In this Review, Shakiba and Tuveson provide an overview of the heterogeneity of cancer-associated fibroblasts and tumor-associated macrophages and how they collaborate to establish an immunosuppressive microenvironment in pancreatic ductal adenocarcinoma.

Vahedi and colleagues review the mechanisms shaping the epigenetic landscape of CD4⁺ and CD8⁺ T cells during development and differentiation.

In this broad Review, the authors describe how the immune response to leukemias develops, how these cancer cells avoid it and how various immunotherapies have been designed to overcome resistance.

In this Review, Matarese and colleagues discuss how immunometabolism controls the physiology and pathophysiology of B cells.

Karin and colleagues review the response of myeloid cells and innate lymphocytes to dietary cues, their cross-regulatory interactions and roles in normal and aberrant metabolic control.

In this Review, Sharma and colleagues describe the current landscape of combination therapies and discuss requirements for the development of effective combination strategies.

In this Review, Herro and Grimes summarize the most recent key findings surrounding protective versus pathogenic functions of neutrophils, elaborating on phenotype-specific subsets of neutrophils and their involvement in homeostasis and disease.

Woolf and colleagues review the current evidence that immune cells could promote pain resolution and prevention through direct effects on sensory neurons and through maintaining healthy tissue innervation.

In this Review, Sarah Cobey discusses how past exposures shape B cell responses to vaccinations with influenza and SARS-CoV-2.

Dolatshahi and Wessel use an in silico modeling approach to predict maternal–fetal IgG transfer selectivity and efficiency in utero that is needed for neonate protection against pathogens.

In this Review, Fitzgerald and Dong summarize the fundamentals of DNA-sensing pathways in health, autoinflammatory and autoimmune diseases.

This Review on the interplay between the immune system and metastasis is part of our wider Series of Reviews on Cancer Immunology and Immunotherapy.

Seder and colleagues review the latest scientific advances in understanding how monoclonal antibodies to the circumsporozoite protein prevent malaria and highlight how this emerging intervention can be used alone or alongside existing antimalarial interventions to control malaria across at-risk populations.

In this Review, the authors analyze functional and dysfunctional T cell features to make sense of cancer immunotherapy efficacy and how to improve it.

In this Review, the author outlines the complex immunology of systemic lupus erythematosus and how to treat it.

In this Review, the authors summarize the literature around immune cancer cell STING signaling and how it is finely balanced between pro-tumorigenic and anti-tumorigenic functions.