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HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women

Nature Medicine volume 1, pages 59–64 (1995)Cite this article

An Erratum to this article was published on 01 June 1995

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Abstract

A crucial requirement in the rational design of a prophylactic vaccine against the hu-uman immunodeficiency virus (HIV) is to establish whether or not protective immunity can occur following natural infection. The immune response to HIV infection is characterized by very vigorous HIV-specific cytotoxic T-lymphocyte (CTL) activity. We have identified four HIV-1 and HIV-2 cross-reactive peptide epitopes, presented to CTL from HIV-infected Gambians by HLA-B35 (the most common Gambian class I HLA molecule). These peptides were used to elicit HIV-specific CTLs from three out of six repeatedly exposed but HIV-seronegative female prostitutes with HLA-B35. These women remain seronegative with no evidence of HIV infection by polymerase chain reaction or viral culture. Their CTL activity may represent protective immunity against HIV infection.

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  • 01 June 1995

    HIV-speciflc cytotoxic T-cells in HIV-exposed but uninfected Gambian women S. Rowland-Jones, J. Sutton, K. Ariyoshi, T. Dong, F. Gotch, S. Mcadam, D. Whitby, S. Sabally, A. Gallimore, T. Corrah, M. Takiguchi, T. Schultz, Andrew Mcmichael & H. Whittle Nature Medicine 1, 59–64, 1995. An error in typography resulted in the incorrect printing of m for the Greek character μ.

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Authors and Affiliations

  1. Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, U.K.

    Sarah Rowland-Jones, Julian Sutton, Tao Dong, Frances Gotch, Steve McAdam, Awen Gallimore & Andre McMichael

  2. MRC Laboratories, P.O. Box 273, Fajara, The Gambia

    Koya Ariyoshi, Sehu Sabally, Tumani Corrah & Hilton Whittle

  3. Chester Beatty Laboratories, The Institute of Cancer Research, 237 Fulham Road, London, SW3 6JB, UK

    Denise Whitby & Thomas Schultz

  4. Department of Tumor Biology, Institute of Medical Science, University of Tokyo, Tokyo, 108, Japan

    Masafumi Takiguchi

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  1. Sarah Rowland-Jones
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  2. Julian Sutton
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  3. Koya Ariyoshi
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Rowland-Jones, S., Sutton, J., Ariyoshi, K. et al. HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women. Nat Med 1, 59–64 (1995). https://doi.org/10.1038/nm0195-59

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